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Vanderbilt's defense will face Austin Peay quarterback Chris Parson after he completed 14 of 21 passes for more than 300 yards and added both passing and rushing touchdowns in the Governors' opener.

Austin Peay complements its vertical passing attack with a deep backfield that produced four players with at least 30 rushing yards and four team rushing touchdowns in Week 0.

Austin Peay replaced seven defensive starters and allowed about 27 points per game in 2025, giving Vanderbilt's offense a favorable matchup despite the Governors improving after halftime in their opener.

Austin Peay intends to involve returning leading receiver Jaden Robinson after he went without a catch in the opener, while Denver Harper emerged with 108 yards and a touchdown on three receptions.

Linebacker Jake Stonebraker is expected back from a lower-body injury against Vanderbilt, while disruptive Charleston Southern transfer David Portu remains conditional after missing the second half of Austin Peay's opener.