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Louisville lists left tackle Anwar O'Neal as probable after he missed the first two games, and offensive lineman Cason Henry is also probable. Bryten Close, Sam Secrest, Max Merz and Cameron Gorin remain out. O'Neal's designation offers potential help to the line, but the initial report does not confirm his return or how the starting lineup would change.

Louisville defensive lineman Demeco Kennedy is questionable on Wednesday's report, while Jeff Brohm had said Monday that the injury suffered against Ole Miss would likely keep him out for two to four weeks. The report and coach's earlier estimate should both be retained; neither establishes that Kennedy is cleared for SMU.

Louisville running back Isaac Brown, defensive back Santana Wilson and receiver Montavin Quisenberry are probable. Keyjuan Brown is absent from the injury report after Brohm had expressed hope Monday that he could return against SMU. No workload or specific rotation for either running back is confirmed.

Louisville's other listed absences are receiver Payton Cook, defensive lineman Sam Dawson, tight end Travis Egan and punter Jacob Baker. Together with the four unavailable offensive linemen, the article identifies eight players as out for SMU; no replacement punter or revised receiver rotation is supplied.