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Key matchup: Louisville vs. Ole Miss
- Game breakdown: I’d love to see your best guess at a 2-deep - sort of an unofficial depth chart.
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Buc-ees
- QB/LB: Cards will have a lot of fans but Miss has a lot of experience especially at QB.
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The Butcher vs. The Spin Instructor -- Week 1
- The Week 1 picks column lists Louisville +6.5 versus Ole Miss and predicts Mississippi 35-17 because of confidence in Trinidad Chambliss and Ole Miss' ability to pressure first-year Louisville starter Lincoln Kienholz.
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Weekend CFB Predictions - Week 1
- The Ole Miss pick lays 6.5 against Louisville because Trinidad Chambliss is viewed as an elite player and the Rebels' defense is expected to pressure first-year Louisville starter Lincoln Kienholz.
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College Football games 9/5
- QB/TE: Dude should have been driving his legs like his mama's life depended on it.
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Gameday Preview: No. 24 Louisville vs. No. 9 Ole Miss
- Ole Miss was listed as a 6.5-point favorite over Louisville with a 55.5 total for the neutral-site opener in Nashville, where the forecast called for an 88-degree kickoff temperature.
- Louisville's defense ranked 16th nationally at 303.1 yards allowed per game and returns five starters, led by edge rusher Clev Lubin after 8.5 sacks and 13.5 tackles for loss.
- Louisville turns its offense over to Ohio State transfer Lincoln Kienholz, a career backup, but surrounds him with explosive returning backs Isaac Brown and Keyjuan Brown, who averaged 8.8 and 7.3 yards per carry last season.
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What Louisville football coach Jeff Brohm had to say before Ole Miss game
- Louisville's inexperienced quarterback played very well in the first fall scrimmage but forced too many vertical throws in the second, making shot selection and ball security Brohm's primary concern against Ole Miss.
- Louisville plans disciplined rush lanes and pressure that keeps Ole Miss quarterback Trinidad Chambliss in the pocket, where the Cardinals can challenge routes without allowing scrambles or extended plays.
- Isaac Brown is healthy and ready after a good camp, and Louisville intends to rotate its deeper running-back room while creating touches for Brown in space.
- Louisville expects to rotate roughly six offensive linemen, with minor injuries affecting the seventh and eighth options, and plans offensive balance to avoid exposing the group to Ole Miss's front through repeated dropbacks.
- Jabari Mack is eligible and will play against Ole Miss, while Kalib Perry has rejoined Louisville but remains ineligible as the staff works through outstanding requirements.
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Louisville vs Ole Miss: Projected Depth Charts
- Louisville's unofficial opener projection places Lincoln Kienholz at quarterback, Isaac Brown at running back, Tre Richardson, LaWayne McCoy and TreyShun Hurry at receiver, and Brody Foley at tight end.
- The projected Louisville offensive line is Lance Robinson, Eryx Daugherty, Evan Wibberley, Johnnie Brown III and Cason Henry from left to right, with Robinson also listed as the backup center.
- Louisville's projected defensive front pairs edge rushers Clev Lubin and AJ Green with tackles Demeco Kennedy and Joshua Donald, while Stanquan Clark and T.J. Capers lead the linebacker projection.
- The projected Louisville secondary starts Tayon Holloway and Kaleb Beasley at corner, DJ Waller and Koen Entringer at safety, and Antonio Watts at the STAR position.
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CardinalAuthority’s Louisville Football Superlatives: Predicting the Cardinals Stat Leaders and Team MVP
- Isaac Brown has averaged 8.8 yards per carry with 21 percent of his attempts gaining at least 10 yards, making his health the key condition behind projections that he leads Louisville in touchdowns and all-purpose production.
- Both analysts projected dual-threat quarterback Lincoln Kienholz to lead Louisville in total yards, with one setting 3,500 combined passing and rushing yards as the benchmark for a productive offense.
- Tulsa transfer Brody Foley is back to health after offseason injuries and enters 2026 as a potential scoring surprise after producing seven receiving touchdowns and two rushing touchdowns last season.
- Edge rusher Clev Lubin returns after leading Louisville with 8.5 sacks, and the Cardinals' depth around him could prevent opponents from concentrating protection solely on him.
- Jeff Brohm said defensive back Jabari Mack is eligible and available for the Ole Miss opener after Mack recorded two interceptions in each of the past two seasons.
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Louisville vs. Ole Miss: Defense seeks early measuring stick in Nashville
- Louisville views Ole Miss quarterback Trinidad Chambliss as an unusually difficult opening test because he combines high-end talent with proven production.
- Louisville's rebuilt defense must also contain Ole Miss running back Kewan Lacy, one of the nation's most productive returning players.
- Co-defensive coordinator Mark Ivey considers the matchup an immediate measuring stick for Louisville's rebuilt defense and believes a strong performance would materially raise the unit's confidence.
- Ivey plans to coach from the sideline while Louisville's defensive staff uses a collaborative game-planning process to put the unit in position against Ole Miss's high-output offense.
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By The Numbers: Louisville vs. Ole Miss
- Louisville enters the neutral-site Ole Miss opener as a 6.5-point underdog with four new offensive-line starters and only 250 career passing yards from first-time starting quarterback Lincoln Kienholz.
- Louisville's established offensive advantage is the backfield, where Isaac Brown averaged a national-best 8.8 yards per carry last season and Keyjuan Brown averaged 7.3.
- Louisville's ACC-leading 2025 pass defense faces an Ole Miss offense that led the SEC at 313.3 passing yards and 498.7 total yards per game last season.
- Louisville edge Clev Lubin enters the matchup with a 91.4 PFF grade that the article identifies as the best among ACC players at his position.
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CardinalAuthority’s Preseason Predictions: Ceiling, Floor, and Most Likely Outcomes
- CardinalAuthority's two preseason projections both place Louisville at 10-2, with that record expected to keep the Cardinals in the ACC Championship and College Football Playoff races.
- The schedule's decisive opening stretch features top-10 Ole Miss in Week 1 and SMU in Week 3, while Louisville avoids ACC preseason favorite Miami during the regular season.
- Louisville's projected ceiling is 11-1 to 12-0 because of its talent, size and depth, with a 3-0 start viewed as the point at which an undefeated run becomes realistic.
- The projected floor is 7-5 to 8-4 if the rebuilt offensive line struggles and the passing game around Lincoln Kienholz develops slowly, especially if Louisville drops the early Ole Miss and SMU games.
- Louisville is 11-8 in one-score games under Jeff Brohm and remains a narrow favorite in several 2026 matchups, adding volatility to a roster viewed as strong on both sides of the ball.
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Podcast: BIG GAME BREAKDOWN: Biggest Storylines + Keys To Win For Clemson-LSU, Louisville-Ole Miss & MORE!
- Cover 3 views Louisville's defense as underrated after the Cardinals added veteran experience to reinforce a secondary that was inconsistent last season.
- Portal receiver Lwayne McCoy was identified as an underrated addition, while another incoming target showed encouraging flashes when healthy at Florida State.
- The panel expects Louisville to rely heavily on its quarterback's mobility against Ole Miss because it remains less confident in his passing and sees his rushing production as central to an upset path.
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Podcast: Episode 254 - 2026 Position Preview | DB
- Louisville returns corners Holloway and Mack, while Waller's length gives him the developmental ceiling to become the secondary's shutdown option.
- Beasley held the practice edge in the safety competition, and Louisville expects the eventual starter to bring SEC experience to the communication-heavy quarterback role in the back end.
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